{"id":4853,"date":"2020-07-03T14:24:48","date_gmt":"2020-07-03T17:24:48","guid":{"rendered":"https:\/\/phelcom.com\/?p=4853"},"modified":"2023-06-01T17:31:57","modified_gmt":"2023-06-01T20:31:57","slug":"coronavirus-vacina-para-cegueira","status":"publish","type":"post","link":"https:\/\/phelcom.com\/pt-br\/blog\/inovacao\/coronavirus-vacina-para-cegueira\/","title":{"rendered":"Coronav\u00edrus: vacina experimental \u00e9 baseada em terapia gen\u00e9tica para cegueira"},"content":{"rendered":"

De fato, o mundo inteiro est\u00e1 correndo para encontrar uma vacina contra a Covid-19. Renomadas universidades, institutos de pesquisas e diversas organiza\u00e7\u00f5es de sa\u00fade trabalham incansavelmente, em diferentes vertentes, para desenvolver a prote\u00e7\u00e3o para o novo coronav\u00edrus (SARS-CoV-2), respons\u00e1vel pela morte de mais de 500 mil pessoas em todo o planeta.<\/p>\n

Um desses projetos \u00e9 o programa de vacinas AAVCOVID, baseado em uma\u00a0terapia g\u00eanica utilizada para tratamento de distrofia da retina heredit\u00e1ria – problema que provoca a perda de vis\u00e3o. Como a tecnologia j\u00e1 \u00e9 aprovada e devido \u00e0 urg\u00eancia frente a atual pandemia, a vacina poderia entrar no mercado em quest\u00e3o de semanas, por exemplo.<\/p>\n

Em seguida, entenda mais sobre esse estudo liderado pelos Estados Unidos e quais ser\u00e3o os pr\u00f3ximos passos.<\/p>\n

A pesquisa<\/h2>\n

Desenvolvido por dois institutos ligados ao Hospital Geral de Massachusetts, em Boston (EUA), o programa de vacina AAVCOVID<\/a> \u00e9 baseado em uma terapia g\u00eanica j\u00e1 aprovada no tratamento de distrofia da retina heredit\u00e1ria e de atrofia muscular espinhal.<\/p>\n

Essa tecnologia utiliza o adenov\u00edrus associado (AAV), testado por mais de duas d\u00e9cadas e comprovadamente seguro para os seres humanos. Al\u00e9m disso, \u00e9 adapt\u00e1vel a diferentes subst\u00e2ncias e alcan\u00e7a resposta imune satisfat\u00f3ria.<\/p>\n

Contra o novo coronav\u00edrus, a ideia \u00e9 usar um vetor AAV para fornecer sequ\u00eancias gen\u00e9ticas do SARS-CoV-2. Desse modo, a vacina\u00e7\u00e3o entrega fragmentos de DNA gen\u00e9tico do v\u00edrus, que gera uma prote\u00edna antig\u00eanica, projetada para provocar uma resposta imune para prevenir a infec\u00e7\u00e3o.<\/p>\n

Ou seja, o AAV fornecer\u00e1 instru\u00e7\u00f5es para a produ\u00e7\u00e3o da chamada prote\u00edna ‘spike’, que auxilia a entrada e a replica\u00e7\u00e3o do coronav\u00edrus na c\u00e9lula. Assim, o sistema imunol\u00f3gico reconhecer\u00e1 como agente externo e produzir\u00e1 anticorpos espec\u00edficos para combater a doen\u00e7a.<\/p>\n

Mesmo se o coronav\u00edrus sofrer muta\u00e7\u00e3o e surgir uma nova cepa, as instru\u00e7\u00f5es gen\u00e9ticas poder\u00e3o ser trocadas. Dessa forma, produzir uma vacina atualizada e em apenas algumas semanas.<\/p>\n

Pr\u00f3ximos passos<\/h2>\n

At\u00e9 o momento, os testes foram realizados apenas em camundongos. Em breve, os experimentos ser\u00e3o feitos em primatas. A expectativa \u00e9 que at\u00e9 o fim do ano o estudo avance para avalia\u00e7\u00f5es em humanos.<\/p>\n

Segundo os pesquisadores, duas vers\u00f5es da vacina \u2013 do total de sete – j\u00e1 est\u00e3o sendo fabricadas para estudos cl\u00ednicos.<\/p>\n

Conclus\u00e3o<\/h2>\n

Sem d\u00favida, a vacina experimental baseada em uma tecnologia j\u00e1 existente de terapia g\u00eanica com adenov\u00edrus associado (AAV) \u00e9 uma grande vantagem. Isso porque, se comprovada a sua efic\u00e1cia, a produ\u00e7\u00e3o de bilh\u00f5es de doses pode ser feita em semanas devido a situa\u00e7\u00e3o emergencial.<\/p>\n

Por outro lado, ainda \u00e9 imprescind\u00edvel mais testes cl\u00ednicos para garantir a seguran\u00e7a e efetividade da nova vacina.<\/p>\n

Acompanhe as novidades sobre coronav\u00edrus e olhos no blog da Phelcom.<\/p>\n","protected":false},"excerpt":{"rendered":"

Saiba mais sobre o programa de vacinas AAVCOVID. <\/p>\n","protected":false},"author":3,"featured_media":4854,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[104],"tags":[],"class_list":["post-4853","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-inovacao"],"acf":[],"yoast_head":"\nCoronav\u00edrus: vacina experimental \u00e9 baseada em terapia gen\u00e9tica para cegueira - PHELCOM Technologies<\/title>\n<meta name=\"description\" content=\"O programa de vacinas contra o coronav\u00edrus "AAVCOVID" \u00e9 baseado em uma\u00a0terapia g\u00eanica utilizada para tratamento de distrofia da retina heredit\u00e1ria.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/phelcom.com\/pt-br\/blog\/inovacao\/coronavirus-vacina-para-cegueira\/\" \/>\n<meta property=\"og:locale\" content=\"pt_BR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Coronav\u00edrus: vacina experimental \u00e9 baseada em terapia gen\u00e9tica para cegueira - 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