{"id":18915,"date":"2022-12-29T16:00:40","date_gmt":"2022-12-29T19:00:40","guid":{"rendered":"https:\/\/phelcom.com\/?p=18915"},"modified":"2023-06-02T14:48:27","modified_gmt":"2023-06-02T17:48:27","slug":"infeccoes-oculares-bacterianas","status":"publish","type":"post","link":"https:\/\/phelcom.com\/pt-br\/blog\/inovacao\/infeccoes-oculares-bacterianas\/","title":{"rendered":"Estudo redescobre drogas n\u00e3o antibi\u00f3ticas para tratamento de infec\u00e7\u00f5es oculares bacterianas\u00a0"},"content":{"rendered":"\n

As infec\u00e7\u00f5es oculares p\u00f3s-operat\u00f3rias s\u00e3o uma grande preocupa\u00e7\u00e3o entre os oftalmologistas, pois podem levar \u00e0 cegueira potencial se n\u00e3o forem tratadas prontamente.\u00a0<\/span><\/p>\n

Nos Estados Unidos, pesquisadores da Wayne State University identificaram tr\u00eas medicamentos n\u00e3o antibi\u00f3ticos que podem proteger o olho de inflama\u00e7\u00f5es graves durante infec\u00e7\u00f5es bacterianas.\u00a0<\/span><\/p>\n

Os medicamentos tamb\u00e9m podem ser usados <\/span>\u200b\u200b<\/span>como terapia adjuvante com antibi\u00f3ticos padr\u00e3o para minimizar os resultados da infec\u00e7\u00e3o. O <\/span>trabalho<\/span><\/a> foi publicado recentemente no peri\u00f3dico iScience.<\/span><\/p>\n

Em seguida, saiba<\/span> como foi feita a pesquisa, os resultados e quais ser\u00e3o os pr\u00f3ximos passos.\u00a0<\/span><\/p>\n

\u00a0<\/p>\n

A pesquisa<\/span><\/h2>\n

\u00a0<\/p>\n

Uma das infec\u00e7\u00f5es mais comuns ap\u00f3s cirurgias oculares \u00e9 a endoftalmite induzida por Staphylococcus aureus, na qual bact\u00e9rias externas ganham acesso ao interior do olho e proliferam.<\/span><\/p>\n

O tratamento atual para essa complica\u00e7\u00e3o envolve antibioticoterapia local ou sist\u00eamica, que reduz a popula\u00e7\u00e3o do microorganismo de modo eficiente, mas faz pouco para reduzir a inflama\u00e7\u00e3o. Cerca de 50% dessas infec\u00e7\u00f5es tamb\u00e9m s\u00e3o causadas por diferentes cepas resistentes a antibi\u00f3ticos, que podem levar ao fracasso do tratamento e \u00e0 perda da vis\u00e3o.<\/span><\/p>\n

Os pesquisadores<\/span> usaram t\u00e9cnicas de transcript\u00f4mica de alto rendimento para entender as altera\u00e7\u00f5es no n\u00edvel do genoma envolvidas na resposta do hospedeiro durante a endoftalmite bacteriana. Para isso, adotaram uma abordagem inovadora de biologia de sistemas para identificar as principais mol\u00e9culas e vias associadas com endoftalmite por Staphylococcus aureus.<\/span><\/p>\n

A equipe previu as tr\u00eas drogas que reverteriam as assinaturas gen\u00e9ticas da endoftalmite bacteriana pelo S.AUREUS, na retina de um modelo animal: Cloreto de Dequal\u00ednio, Tosilato de Clofilium e Glibenclamida.<\/span><\/p>\n

\u00a0<\/p>\n

\"Infec\u00e7\u00f5es<\/a>

Ashok Kumar, Ph.D., \u00e0 esquerda, e Susmita Das, Ph.D.<\/p><\/div>\n

\u00a0<\/p>\n

Os resultados<\/span><\/h2>\n

\u00a0<\/p>\n

O estudo testou a efic\u00e1cia das drogas e descobriu que todas exibiam propriedades anti-inflamat\u00f3rias contra cepas bacterianas sens\u00edveis e resistentes a antibi\u00f3ticos em c\u00e9lulas retinianas cultivadas.<\/span><\/p>\n

\u201cEnquanto as inje\u00e7\u00f5es intrav\u00edtreas de todas as drogas reduziram a inflama\u00e7\u00e3o intraocular, mesmo em olhos de camundongos infectados por SA resistentes \u00e0 meticilina; DC e CT foram capazes de reduzir a carga bacteriana tamb\u00e9m.\u00a0Os tratamentos medicamentosos melhoraram a fun\u00e7\u00e3o visual e protegeram o olho da morte das c\u00e9lulas da retina\u201d, disse em comunicado a pesquisadora <\/span>Susmita Das<\/span>.<\/span><\/p>\n

\u201cTamb\u00e9m quer\u00edamos verificar o resultado da doen\u00e7a ap\u00f3s uma terapia adjuvante desses medicamentos com o tratamento antibi\u00f3tico existente durante a infec\u00e7\u00e3o ocular e descobrimos que esses medicamentos demonstraram sinergia com a vancomicina na melhora da gravidade da doen\u00e7a\u201d, acrescentou o professor e pesquisador <\/span>Ashok Kumar<\/span>.\u00a0<\/span><\/p>\n

Agora, os cientistas est\u00e3o investigando os mecanismos subjacentes \u00e0s propriedades antimicrobianas e anti-inflamat\u00f3rias dessas drogas e testando sua efic\u00e1cia contra outros pat\u00f3genos bacterianos, a fim de elucidar completamente a intera\u00e7\u00e3o entre as drogas, o hospedeiro e o microoganismo.<\/span><\/p>\n

\u00a0<\/p>\n

Revisado por Paulo Schor, m\u00e9dico oftalmologista, professor livre docente e diretor de inova\u00e7\u00e3o da Universidade Federal de S\u00e3o Paulo (Unifesp) e colaborador da Faculdade de Medicina do Hospital Albert Einstein.<\/span><\/i><\/p>\n

\u00a0<\/span><\/p>\n

Acompanhe o blog da Phelcom e fique por dentro das principais novidades sobre infec\u00e7\u00f5es oculares bacterianas.\u00a0<\/span><\/p>\n\n\n","protected":false},"excerpt":{"rendered":"

Os medicamentos tamb\u00e9m podem ser usados \u200b\u200bcomo terapia adjuvante com antibi\u00f3ticos padr\u00e3o para minimizar os resultados da infec\u00e7\u00e3o. <\/p>\n","protected":false},"author":3,"featured_media":18949,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[104],"tags":[],"class_list":["post-18915","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-inovacao"],"acf":[],"yoast_head":"\nEstudo redescobre drogas n\u00e3o antibi\u00f3ticas para tratamento de infec\u00e7\u00f5es oculares bacterianas\u00a0 - PHELCOM Technologies<\/title>\n<meta name=\"description\" content=\"Os medicamentos tamb\u00e9m podem ser usados \u200b\u200bcomo terapia adjuvante com antibi\u00f3ticos padr\u00e3o para minimizar as infec\u00e7\u00f5es oculares bacterianas.\u00a0\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/phelcom.com\/pt-br\/blog\/inovacao\/infeccoes-oculares-bacterianas\/\" \/>\n<meta property=\"og:locale\" content=\"pt_BR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Estudo redescobre drogas n\u00e3o antibi\u00f3ticas para tratamento de infec\u00e7\u00f5es oculares bacterianas\u00a0 - 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